The present invention provides an ammunition disabler with a material capable of being selectively changed in response to an energy wave for preemptively disabling ammunition. In at least one embodiment, the ammunition disabler includes a material selectively structurally changeable from an operative state to a deactivated state upon exposure to an energy wave is provided, where the material is positioned at least partially between the firing pin and the priming compound when the ammunition is chambered within the firearm (with the priming compound positioned between the material and the propellant), and related systems, methods and uses. The material may be contained within the primer cup with the priming compound. The material may be positioned adjacent to the priming compound in direct or indirect contact or in close proximity. The material may be positioned externally from the primer cup.