- 专利标题： Drug conjugate comprising anti-CDH3 (P-cadherin) antibody
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申请号： US14390734申请日： 2012-04-04
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公开(公告)号： US09764041B2公开(公告)日： 2017-09-19
- 发明人: Keisuke Ishii , Katsuyuki Mitomo , Katsushi Kouda , Fumiko Nomura , Yoko Kayukawa , Tadashi Matsuura
- 申请人： Keisuke Ishii , Katsuyuki Mitomo , Katsushi Kouda , Fumiko Nomura , Yoko Kayukawa , Tadashi Matsuura
- 申请人地址： JP Tokyo
- 专利权人： PERSEUS PROTEOMICS INC.
- 当前专利权人： PERSEUS PROTEOMICS INC.
- 当前专利权人地址： JP Tokyo
- 代理机构： Birch, Stewart, Kolasch & Birch, LLP
- 国际申请： PCT/JP2012/059236 WO 20120404
- 国际公布： WO2013/150623 WO 20131010
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; A61K47/48 ; C07K16/28 ; C07K16/30
摘要：
It is an object of the present invention to provide a drug conjugate comprising an anti-CDH3 antibody that efficiently kills cancer cells expressing CDH3. According to the present invention, there is provided an immune complex formed by binding an antibody against CDH3 or a fragment thereof having CDH3 binding ability to a chemotherapeutic agent.
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