An imaging system may have a pixel array that includes a first group of pixels and a second group of pixels that generate image signals in response to light received from a scene. Image signals generated by the first group of pixels may be read out using a first skipping pattern and/or binning factor and image signals generated by the second group of pixels may be read out using a second skipping pattern and/or binning factor. The first and second skipping patterns and/or binning may be different and may be weighted based on the amount of image data that is available for different portions of the scene. An image may be generated based on the image signals that are read out from the first and second groups. Perspective correction operations may be used to correct for perspective distortion in the image.