- 专利标题： Inhibitory oligonucleotide and use thereof
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申请号： US14442799申请日： 2012-11-29
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公开(公告)号： US09688992B2公开(公告)日： 2017-06-27
- 发明人: Eiji Esashi , Liying Wang , Yongli Yu
- 申请人： SBI Biotech Co., Ltd.
- 申请人地址： JP Tokyo
- 专利权人： SBI Biotech Co., Ltd.
- 当前专利权人： SBI Biotech Co., Ltd.
- 当前专利权人地址： JP Tokyo
- 代理机构： Fish & Richardson P.C.
- 国际申请： PCT/CN2012/085547 WO 20121129
- 国际公布： WO2014/082254 WO 20140625
- 主分类号： C12N15/117
- IPC分类号： C12N15/117 ; A61P37/02 ; A61P37/06 ; A61K31/711 ; A61K47/48
摘要：
The inhibitory oligonucleotides (ODNs) which strongly block NF-κB activation induced by TLR9 agonists and TLR7 agonists are provided. The production of proinflammatory cytokines, such as interleukin-6 and tumor necrosis factor alpha, is inhibited by the inhibitory-ODNs. Interferon production from human PBMC induced by TLR9 agonist is prevented by the inhibitory-ODNs. These ODNs can be used as a remedy for the treatment of immune-mediated disorders such as rheumatoid arthritis, systemic lupus erythematosus (SLE), sepsis, multiple organ dysfunction syndromes.
公开/授权文献
- US20150299710A1 Inhibitory Oligonucleotide and Use Thereof 公开/授权日：2015-10-22
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