![N-(2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-5-yl)-4-quinazolinamine and N-(2,3-dihydro-1H-indol-5-yl)-4-quinazolinamine derivatives as perk inhibitors](/docs/US/2017-06-27/US09688662B2/abs.jpg.600x600.jpg)
- 专利标题： N-(2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-5-yl)-4-quinazolinamine and N-(2,3-dihydro-1H-indol-5-yl)-4-quinazolinamine derivatives as perk inhibitors
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申请号： US14782091申请日： 2014-03-31
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公开(公告)号： US09688662B2公开(公告)日： 2017-06-27
- 发明人: Ian Stansfield , Yannick Aime Eddy Ligny , Nathalie Claudie Isabelle Amblard , Matthias Luc Aime Versele
- 申请人： Janssen Pharmaceutica NV
- 申请人地址： BE Beerse
- 专利权人： Janssen Pharmaceutica NV
- 当前专利权人： Janssen Pharmaceutica NV
- 当前专利权人地址： BE Beerse
- 优先权： EP13162362 20130404
- 国际申请： PCT/EP2014/056430 WO 20140331
- 国际公布： WO2014/161808 WO 20141009
- 主分类号： A61K31/4045
- IPC分类号： A61K31/4045 ; A61K31/407 ; A61K31/517 ; C07D239/72 ; C07D403/12 ; C07D405/14 ; C07D413/14 ; C07D403/14 ; C07D409/14 ; C07D471/04 ; C07D491/056
![N-(2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-5-yl)-4-quinazolinamine and N-(2,3-dihydro-1H-indol-5-yl)-4-quinazolinamine derivatives as perk inhibitors](/abs-image/US/2017/06/27/US09688662B2/abs.jpg.150x150.jpg)
摘要：
The present invention relates to N-(2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-5-yl)-4-quinazolinamine and N-(2,3-dihydro-1H-indol-5-yl)-4-quinazolinamine derivatives of Formula (I) wherein R1, R2, R3, R4, R5, R6 and A have the meaning defined in the claims. The compounds according to the present invention are useful as inhibitors of PERK. The invention further relates to processes for preparing such compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.
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