A frame-shaped, essentially rectangular spacer for pipette tip carriers stacked one on top of another includes a horizontal base surface, a peripheral side wall, which stands essentially perpendicular to the base surface and forms two longitudinal sides and two transverse sides, and an upper surface. Each longitudinal side and transverse side includes an inner side. The upper surface is arranged at an upper end of the side wall and essentially horizontally. The spacer is implemented to form a stabilizing support connection with an essentially rectangular pipette tip carrier positioned on the spacer. In addition, the spacer includes centering spring elements, which are arranged on the inner side of all longitudinal sides and transverse sides, having a springy part spaced apart in relation to the inner side of the respective side wall.