A Network Node and a method therein for controlling uplink power control are provided. The method comprises collecting (210) measurement reports from UEs. The method comprises creating (220) clusters of low power RBS(s) and macro RBS(s), wherein each cluster comprises one low power RBS and at least one macro RBS; and identifying (230) the macro RBS with the lowest pathloss for those UEs connected to the low power RBS and the level of the pathloss. The method comprises determining (240) an interference level in the low power RBS caused by UEs connected to the macro RBS for those UEs connected to the macro RBS. Further, the method comprises selecting (250) uplink power control setting for the low power RBS based on the size of the pathloss associated with the identified macro RBS and the interference level in the low power RBS caused by UEs being connected to the macro RBS.