Invention Grant
- Patent Title: Tetrahydronaphthyridine and related bicyclic compounds for inhibition of RORγ activity and the treatment of disease
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Application No.: US14398061Application Date: 2013-05-07
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Publication No.: US09657033B2Publication Date: 2017-05-23
- Inventor: Thomas D. Aicher , Kenneth J. Barr , Blair T. Lapointe , Vladimir Simov , Karin A. Stein , William D. Thomas , Peter L. Toogood , Chad A. Van Huis , Catherine M. White
- Applicant: Merck Sharp & Dohme Corp. , Lycera Corporation
- Applicant Address: US MI Ann Arbor US NJ Rahway
- Assignee: Lycera Corporation,Merck Sharp & Dohme Corp.
- Current Assignee: Lycera Corporation,Merck Sharp & Dohme Corp.
- Current Assignee Address: US MI Ann Arbor US NJ Rahway
- Agency: Goodwin Procter LLP
- International Application: PCT/US2013/039839 WO 20130507
- International Announcement: WO2013/169704 WO 20131114
- Main IPC: A61K31/397
- IPC: A61K31/397 ; C07D498/04 ; C07D413/06 ; C07D471/04
Abstract:
The invention provides tetrahydronaphthyridine and related compounds, pharmaceutical compositions, methods of inhibiting RORγ activity, reducing the amount of IL-17 in a subject, and treating immune disorders and inflammatory disorders using such tetrahydronaphthyridine and related compounds.
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