- 专利标题: Pharmaceutical dosage forms comprising valganciclovir hydrochloride
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申请号: US14529839申请日: 2014-10-31
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公开(公告)号: US09642911B2公开(公告)日: 2017-05-09
- 发明人: Maria Oksana Bachynsky , Martin Howard Infeld , Navnit Hargovindas Shah
- 申请人: Hoffmann-La Roche Inc.
- 申请人地址: US NJ Little Falls
- 专利权人: Hoffmann-La Roche Inc.
- 当前专利权人: Hoffmann-La Roche Inc.
- 当前专利权人地址: US NJ Little Falls
- 代理机构: Genentech, Inc.
- 代理商 Mark D. Kafka
- 主分类号: A61K47/12
- IPC分类号: A61K47/12 ; A61K47/10 ; A61K31/522 ; A61K9/00 ; A61K9/16
摘要:
The present invention provides novel solid pharmaceutical dosage forms for oral administration, after being constituted in water. The solid dosage forms comprise a therapeutically effective amount of valganciclovir hydrochloride and a non-hygroscopic organic acid present in an amount sufficient to stabilize the valganciclovir hydrochloride in a predetermined amount of water. The present invention also provides novel liquid pharmaceutical dosage forms for oral administration after constituting the solid pharmaceutical dosage form with water. A non-hygroscopic bulking agent may optionally be included in the above dosage form. These novel pharmaceutical dosage forms are useful in the treatment or control of viruses such as herpes simplex virus and cytomegalovirus. The present invention also provides a method for treating these diseases employing the solid and liquid pharmaceutical dosage forms and a method for preparing these pharmaceutical dosage forms.
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