- 专利标题： Formulations of guanylate cyclase C agonists and methods of use
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申请号： US13421769申请日： 2012-03-15
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公开(公告)号： US09616097B2公开(公告)日： 2017-04-11
- 发明人: Stephen Comiskey , Rong Feng , John Foss , Kunwar Shailubhai
- 申请人： Stephen Comiskey , Rong Feng , John Foss , Kunwar Shailubhai
- 申请人地址： US NY New York
- 专利权人： SYNERGY PHARMACEUTICALS, INC.
- 当前专利权人： SYNERGY PHARMACEUTICALS, INC.
- 当前专利权人地址： US NY New York
- 代理商 Cynthia A. Kozakiewicz; Ivor Elrifi
- 主分类号： A61K38/10
- IPC分类号： A61K38/10 ; A61K38/12 ; A61K9/16 ; A61K9/20 ; A61K9/48 ; A61K45/06 ; C07K7/08 ; C07K7/64
摘要：
The invention provides low-dose formulations of guanylate cyclase-C (“GCC”) agonist peptides and methods for their use. The formulations of the invention can be administered either alone or in combination with one or more additional therapeutic agents, preferably an inhibitor of cGMP-dependent phosphodiesterase or a laxative.
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