The present devices and methods are configured to utilize ultra-low frequency non-vibratory tactile stimuli for the regulation of physiological processes. In one embodiment, an apparatus configured to generate and apply mechanical stimuli to skin of a user for regulating a physiological process includes a housing having a first surface for placement against the skin and an electro-mechanical actuator disposed within the housing and configured to generate and apply the mechanical stimuli to the skin. The mechanical stimuli comprise ultra-low frequency stimuli that have a frequency between about 2 Hz (two stimuli per second) to about 0.1 Hz (one stimulus every 10 seconds). The mechanical stimuli have sufficient energy so as to engage skin sensory receptors that are configured to convey signals to the nervous system where the stimuli are at least one of consciously perceived and subliminally perceived.