发明授权
- 专利标题： Bacteria carrying bacteriophage and protease inhibitors for the treatment of disorders and methods of treatment
- 专利标题（中）： 携带噬菌体和蛋白酶抑制剂的细菌用于治疗疾病和治疗方法
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申请号： US14180766申请日： 2014-02-14
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公开(公告)号： US09593339B1公开(公告)日： 2017-03-14
- 发明人: David Gordon Bermudes
- 申请人： David Gordon Bermudes
- 代理机构： Ostrolenk Faber LLP
- 代理商 Steven M. Hoffberg, Esq.
- 主分类号： A61K35/74
- IPC分类号： A61K35/74 ; A61K35/76 ; A61K38/00 ; A61K39/00 ; C12N15/74 ; A61K31/7105 ; A61K31/713 ; A61K38/55 ; A61K39/395
摘要：
The present invention uses co-expression of protease inhibitors and protease sensitive therapeutic agents including phage and phagemids delivering peptides, therapeutic antibodies, DNA and RNA-based therapeutics that results in treating inflammation of a variety of disorders including psoriasis, atopic dermatitis and inflammatory bowel disease. The invention also provides bacteria that inhibit the growth of intestinal parasites such as worms, and deliver siRNA or miRNA that have specific anti-parasitic effects that results in the reduction or elimination of the parasite.
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