发明授权
US09593127B2 Heterocyclylalkyne derivatives and their use as modulators of mGluR5 receptors
有权
杂环炔基衍生物及其作为mGluR5受体调节剂的用途
- 专利标题： Heterocyclylalkyne derivatives and their use as modulators of mGluR5 receptors
- 专利标题（中）： 杂环炔基衍生物及其作为mGluR5受体调节剂的用途
-
申请号： US14983277申请日： 2015-12-29
-
公开(公告)号： US09593127B2公开(公告)日： 2017-03-14
- 发明人: Carlo Riva , Carlo De Toma , Patrizia Angelico , Elena Poggesi , Davide Graziani
- 申请人： RECORDATI IRELAND LTD.
- 申请人地址： IE
- 专利权人： RECORDATI IRELAND LTD.
- 当前专利权人： RECORDATI IRELAND LTD.
- 当前专利权人地址： IE
- 代理机构： Leason Ellis LLP
- 主分类号： C07D498/04
- IPC分类号： C07D498/04 ; A61K31/424
摘要：
This invention relates to compounds of formula I, their use as allosteric modulators of mGluR5 receptor activity, pharmaceutical compositions containing the same, and methods of using the same as agents for the treatment and/or prevention of neurological and psychiatric disorders associated with glutamate dysfunction, such as schizophrenia or cognitive decline, dementia or cognitive impairment, or other pathologies that can be related directly or indirectly to glutamate dysfunction.
公开/授权文献
信息查询
