发明授权
- 专利标题: Benzoazepine derivative and medical use thereof
- 专利标题(中): 苯并氮平衍生物及其医疗用途
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申请号: US14438920申请日: 2013-12-26
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公开(公告)号: US09586905B2公开(公告)日: 2017-03-07
- 发明人: Katsunori Kitamoto , Nobuyoshi Kasugai , Hiroyo Kataoka , Yasushi Ohsawa , Yuka Kuno , Hiroki Fujieda , Keita Sakai , Hiroki Nagano , Naoki Takahashi , Toru Izuchi , Mitsuaki Takeuchi , Daisuke Kurumazuka , Toshiyuki Miyazawa , Satoko Harada , Izumi Gotoh , Yukiyasu Asano , Yurie Yamada , Morio Okabe
- 申请人: SANWA KAGAKU KENKYUSHO CO., LTD.
- 申请人地址: JP Nagoya-shi
- 专利权人: SANWA KAGAKU KENKYUSHO CO., LTD.
- 当前专利权人: SANWA KAGAKU KENKYUSHO CO., LTD.
- 当前专利权人地址: JP Nagoya-shi
- 代理机构: Oliff PLC
- 优先权: JP2012-281908 20121226
- 国际申请: PCT/JP2013/084937 WO 20131226
- 国际公布: WO2014/104209 WO 20140703
- 主分类号: A61K31/55
- IPC分类号: A61K31/55 ; C07D223/16 ; C07D403/02 ; C07D403/14 ; C07D413/02 ; C07D413/14 ; C07D403/10 ; C07D413/10 ; C07D403/12 ; C07D413/12
摘要:
A compound having a V2 receptor agonistic activity is provided. Providing a pharmaceutical composition which contains, as an active ingredient, a compound represented by general formula (I) described below: [R1 is formula described below: (A is a lower alkylene group which may be substituted with lower alkyl group; R6 is a hydrogen atom; R7 is a hydroxyl group, an aromatic heterocyclic group which may be substituted with lower alkyl group, carbamoyl group); R2 is a hydrogen atom or lower alkyl group; R3 is lower alkyl group which may be substituted with 1-3 fluorine atoms, or halogen atom; R4 is a five-membered aromatic monocyclic heterocyclic group, five-membered non-aromatic monocyclic heterocyclic group, (provided each heterocyclic groups contain at least one nitrogen atom and may be substituted with a lower alkyl group); and R5 is a lower alkyl group, halogen atom], or pharmacologically acceptable salt thereof.
公开/授权文献
- US20150291533A1 NOVEL BENZOAZEPINE DERIVATIVE AND MEDICAL USE THEREOF 公开/授权日:2015-10-15
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