A method and apparatus for transmitting an uplink signal in a wireless communication system are disclosed. A transmission apparatus for receiving an uplink (UL) signal from a user equipment (UE) and transmitting the received UL signal to a base station (BS) in a wireless communication system includes: a plurality of reception antennas configured to receive UL signals from the UE; a radio frequency (RF) repeater configured to amplify and map the received UL signals to at least one transmission antenna; and a plurality of transmission antennas configured to transmit the amplified UL signals to the BS, wherein the RF repeater is configured to select M received UL signals from among a plurality of received UL signals which are received in the plurality of reception antennas, and map the M received UL signals to N transmission antennas from among the plurality of transmission antennas, and the number of the reception antennas (Nrx,REP) is higher than the number of the transmission antennas (Ntx,REP), and N is the number of the transmission antennas which is used to transmit the M received UL signals.