The present invention relates to a thin film transistor array substrate and a method of manufacturing the same. The thin film transistor array substrate may comprise a substrate which has a plurality of gate lines extending in a column direction along a boundary of pixels, a plurality of data lines extending in a row direction along the boundary of the pixels, and at least one thin film transistor formed in the pixel region; a first insulating film which covers the thin film transistor; a color organic film which is disposed on the first insulating film and has a valley area formed with a valley by partial superimposition of organic films of different colors based on the data lines; a second insulating film which covers the color organic film and the valley area; and a pixel electrode which is disposed on the second insulating film and connected to the thin film transistor via a contact hole, wherein the thin film transistor array substrate is provided with a separating organic film which extends from the color organic film and is disposed between the valley area and the contact hole.