Embodiments of the disclosure include an LED lamp driving method and a system in the liquid crystal panel display field. A method of the disclosure includes: adjusting correspondence relations between ports of the LED lamp and channel ports of the LED lamp driving chip first; and then connecting ports of the LED lamp and channel ports of the LED lamp driving chip according to the adjusted the correspondence relations to control light emission of the LED lamp. Aspects of the disclosure include avoiding overheating and even burning of LED lamp driving chips; can be adapted to various LED lamps operation to reduce failure rate of LED lamp operation to the minimum; effectively reduces concentrated heating of the LED lamp driving chip and increases service life of the LED lamp driving chip.