A sensing circuit for an electrochemical sensor includes a digital-to-analog converter (DAC), an operational amplifier, an instrumentation amplifier, and an analog-to-digital converter (ADC). The DAC generates a biased ground voltage signal which is received by the operational amplifier. The operational amplifier creates a high current biased voltage on one of a pair of terminals connected to the electrochemical sensor. The instrumentation amplifier receives a signal from the pair of terminals, and generates an output representative of a voltage across the pair of terminals with reference to the high current biased ground voltage signal. The ADC converter receives the output and derives an actual voltage reading taken by the electrochemical sensor.