A battery depassivation system includes a depassivation circuit, a battery connect/disconnect circuit, and a processor. The depassivation circuit is adapted to be electrically coupled in series with a battery. The depassivation circuit is also coupled to receive an ENABLE signal and is configured, upon receipt thereof, to draw current from the battery. The battery connect/disconnect circuit is adapted to be electrically coupled in series between the battery and one or more battery-powered electronic circuits. The battery connect/disconnect circuit is coupled to receive an ISOLATE signal and is configured, upon receipt thereof, to electrically disconnect the one or more battery-powered electronic circuits from the battery. The processor is adapted to couple to the battery and is configured, upon being coupled thereto, to determine if the battery needs depassivation and implement a depassivation routine if the battery is determined to need depassivation.