发明授权
- 专利标题: Bone cements containing magnetic calcium phosphate nanoparticles
- 专利标题(中): 含有磁性磷酸钙纳米粒子的骨水泥
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申请号: US14083215申请日: 2013-11-18
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公开(公告)号: US09566216B2公开(公告)日: 2017-02-14
- 发明人: Xingguo Cheng , Daniel P. Nicolella , Todd L. Bredbenner
- 申请人: Southwest Research Institute
- 申请人地址: US TX San Antonio
- 专利权人: SOUTHWEST RESEARCH INSTITUTE
- 当前专利权人: SOUTHWEST RESEARCH INSTITUTE
- 当前专利权人地址: US TX San Antonio
- 代理机构: Grossman Tucker et al
- 主分类号: A61K6/083
- IPC分类号: A61K6/083 ; A61F2/30 ; A61K6/06 ; A61K49/18 ; A61L24/00 ; A61K6/00 ; A61K6/02
摘要:
A bone cement formulation comprising: (a) magnetic calcium phosphate nanoparticles present in an amount of 5.0-95 wt. % and having a largest linear dimension of 150 nm to 50 microns; (b) polymerizable acrylate monomer present in an amount of 5.0-95 wt. %; and (c) polyacrylate polymer present in an amount of 0-80 wt. % and having a largest linear dimension from 5.0 to 500 microns. Upon exposure to an alternating magnetic field the formulation is heated which results in polymerization of the acrylate monomer component. The formulation may also be polymerized via the use of chain polymerization initiators.
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