发明授权
US09556216B2 2′-Ethynyl nucleoside derivatives for treatment of viral infections
有权
用于治疗病毒感染的2'-乙炔基核苷衍生物
- 专利标题： 2′-Ethynyl nucleoside derivatives for treatment of viral infections
- 专利标题（中）： 用于治疗病毒感染的2'-乙炔基核苷衍生物
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申请号： US14421249申请日： 2013-08-27
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公开(公告)号： US09556216B2公开(公告)日： 2017-01-31
- 发明人: Sampath-Kumar Anandan , Virender Singh Aulakh , Martijn Fenaux , Xiaodong Lin , Liang Mao , Oliver Saunders , Zachary Kevin Sweeney , Fumiaki Yokokawa , Weidong Zhong
- 申请人： Sampath-Kumar Anandan , Virender Singh Aulakh , Martijn Fenaux , Xiaodong Lin , Liang Mao , Oliver Saunders , Zachary Kevin Sweeney , Fumiaki Yokokawa , Weidong Zhong
- 申请人地址： CH Basel
- 专利权人： Novartis AG
- 当前专利权人： Novartis AG
- 当前专利权人地址： CH Basel
- 代理商 Michael G. Smith
- 优先权： WOPCT/CN2013/073443 20130329
- 国际申请： PCT/IB2013/056898 WO 20130827
- 国际公布： WO2014/033617 WO 20140306
- 主分类号： C07H19/10
- IPC分类号： C07H19/10 ; A61K31/7072 ; A61K31/7068 ; A61K45/06
摘要：
The present invention provides a compound of formula A: or a pharmaceutically acceptable salt thereof, wherein B, Q, R1, R5, R6, R7, R8 and Z are as defined herein, which is a 2′-branched nucleoside useful for the treatment or prevention of viral infections, particularly dengue fever, yellow fever, West Nile virus, Japanese encephalitis virus, tick-borne encephalitis virus, Kunjin virus, Murray Valley encephalitis, St Louis encephalitis, Omsk hemorrhagic fever virus, bovine viral diarrhea virus, Zika virus and Hepatitis C virus.
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