发明授权
- 专利标题: Ionic aqueous solutions comprising charge-stabilized oxygen-containing nanobubbles
- 专利标题(中): 包含电荷稳定的含氧纳米气泡的离子水溶液
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申请号: US13851888申请日: 2013-03-27
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公开(公告)号: US09511333B2公开(公告)日: 2016-12-06
- 发明人: Anthony B. Wood , Gregory J. Archambeau , Richard L. Watson
- 申请人: Revalesio Corporation
- 申请人地址: US WA Tacoma
- 专利权人: Revalesio Corporation
- 当前专利权人: Revalesio Corporation
- 当前专利权人地址: US WA Tacoma
- 代理机构: Davis Wright Tremaine LLP
- 代理商 Barry L. Davison
- 主分类号: A61J3/00
- IPC分类号: A61J3/00 ; A61K33/00 ; A61K9/10 ; B01F5/06 ; B01F3/04 ; B01F3/08 ; B01F7/00 ; C09K3/00
摘要:
Provided are electrokinetically-altered fluids (e.g., gas-enriched (e.g., oxygen-enriched) electrokinetic fluids) comprising an ionic aqueous solution of charge-stabilized oxygen-containing nanostructures in an amount sufficient to provide, upon contact with a cell, modulation of at least one of cellular membrane potential and cellular membrane conductivity. Further provided are the methods of making the electrokinetically-altered ionic aqueous fluid compositions. Particular aspects provide for regulating or modulating intracellular signal transduction associated by modulation of at least one of cellular membranes, membrane potential, membrane proteins such as membrane receptors, including but not limited to G-Protein Coupled Receptors (GPCR), and intercellular junctions (e.g., tight junctions, gap junctions, zona adherins and desmasomes). Other embodiments include particular methods of producing the electrokinetically-altered fluids. The electrokinetically-altered fluid compositions and methods of producing the fluid include electrokinetically-altered ionic aqueous fluids optionally in the form of solvated electrons stabilized with molecular oxygen.
公开/授权文献
- US20130295144A1 MIXING DEVICE 公开/授权日:2013-11-07
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