Invention Grant
- Patent Title: Prodrugs and methods of use thereof
- Patent Title (中): 前药及其使用方法
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Application No.: US14423359Application Date: 2013-08-22
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Publication No.: US09505791B2Publication Date: 2016-11-29
- Inventor: Jeffrey Bruce Smaill , Adam Vorn Patterson , Amir Ashoorzadeh , Christopher Paul Guise , Alexandra Marie Mowday , David Francis Ackerley , Elsie May Williams , Janine Naomi Copp
- Applicant: Jeffrey Bruce Smaill , Adam Vorn Patterson , Amir Ashoorzadeh , Christopher Paul Guise , Alexandra Marie Mowday , David Francis Ackerley , Elsie May Williams , Janine Naomi Copp
- Applicant Address: NL Maastricht
- Assignee: Health Innovation Ventures B.V.
- Current Assignee: Health Innovation Ventures B.V.
- Current Assignee Address: NL Maastricht
- Agency: Fitch Even Tabin & Flannery LLP
- Priority: NZ602004 20120823
- International Application: PCT/NZ2013/000150 WO 20130822
- International Announcement: WO2014/031012 WO 20140227
- Main IPC: C07F9/09
- IPC: C07F9/09 ; C07C255/58 ; C07C309/66 ; C07C317/48 ; C07D295/13 ; C07D295/192 ; C07C309/69 ; C07C317/36 ; C07D295/104
Abstract:
The invention relates to compounds of use as targeted cytotoxic agents and methods of use thereof. In particular, the invention relates to prodrugs that are substantially resistant to human AKR1C3 enzyme metabolism, methods of cell ablation using said compounds and methods of treatment of cancer and other hyperproliferative disorders using said compounds.
Public/Granted literature
- US20150299230A1 Novel Prodrugs And Methods Of Use Thereof Public/Granted day:2015-10-22
Information query
