发明授权
- 专利标题： Antimetabolite agent combinations in the treatment of cancer
- 专利标题（中）： 抗代谢药物组合治疗癌症
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申请号： US12762768申请日： 2010-04-19
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公开(公告)号： US09498489B2公开(公告)日： 2016-11-22
- 发明人: Lili Liu , Stanton Gerson
- 申请人： Lili Liu , Stanton Gerson
- 申请人地址： US OH Cleveland
- 专利权人： Case Western Reserve University
- 当前专利权人： Case Western Reserve University
- 当前专利权人地址： US OH Cleveland
- 代理机构： Tarolli, Sundheim, Covell & Tummino LLP
- 主分类号： A61K31/7068
- IPC分类号： A61K31/7068 ; C07H19/12 ; A61K31/7028
摘要：
A method treating cancer in a subject comprises administering to the subject a therapeutically effective amount of an antimetabolite agent that induces formation of AP sites in cancer cells of the subjects and an amount AP endonuclease inhibitor effective to potentiate the cytotoxicity of the antimetabolite agent to the cancer cells.
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