Invention Grant
US09494669B2 Diagnosis of central nervous system white matter pathology using diffusion MRI
有权
诊断中枢神经系统白质病变使用扩散MRI
- Patent Title: Diagnosis of central nervous system white matter pathology using diffusion MRI
- Patent Title (中): 诊断中枢神经系统白质病变使用扩散MRI
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Application No.: US13109986Application Date: 2011-05-17
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Publication No.: US09494669B2Publication Date: 2016-11-15
- Inventor: Sheng-Kwei Song , Qing Wang , Yong Wang
- Applicant: Sheng-Kwei Song , Qing Wang , Yong Wang
- Applicant Address: US MO St. Louis
- Assignee: Washington University
- Current Assignee: Washington University
- Current Assignee Address: US MO St. Louis
- Agency: Armstrong Teasdale LLP
- Main IPC: A61B5/055
- IPC: A61B5/055 ; G01R33/563

Abstract:
Determining diffusivity of multiple diffusion components within a tissue using diffusion magnetic resonance data representing a volume of the tissue. A plurality of candidate fibers having a direction is defined within the volume. A possibility coefficient is calculated by a processor for each candidate fiber of the plurality of candidate fibers based on the magnetic resonance data and the direction of the candidate fiber. The possibility coefficient represents a likelihood that the candidate fiber exists in the volume. Candidate fibers associated with a possibility coefficient greater than a threshold value are selected by the processor to create one or more probable fibers. For each probable fiber of the one or more probable fibers, an axial diffusivity indicating a diffusion of water in the direction of the probable fiber and a radial diffusivity indicating a diffusion of water perpendicular to the direction of the probable fiber are calculated by the processor. The diffusivity of isotropic diffusion component and the volume ratios of each fiber component and isotropic components are calculated.
Public/Granted literature
- US20110282183A1 Diagnosis Of Central Nervous System White Matter Pathology Using Diffusion MRI Public/Granted day:2011-11-17
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