发明授权
- 专利标题： Cell culture process
- 专利标题（中）： 细胞培养过程
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申请号： US14131005申请日： 2012-07-06
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公开(公告)号： US09475858B2公开(公告)日： 2016-10-25
- 发明人: Holly Prentice
- 申请人： Holly Prentice
- 申请人地址： US MA Cambridge
- 专利权人： Momenta Pharmaceuticals, Inc.
- 当前专利权人： Momenta Pharmaceuticals, Inc.
- 当前专利权人地址： US MA Cambridge
- 代理机构： Choate, Hall & Stewart LLP
- 国际申请： PCT/US2012/045848 WO 20120706
- 国际公布： WO2013/009648 WO 20130117
- 主分类号： C12P21/06
- IPC分类号： C12P21/06 ; C12N5/10 ; C07K16/00 ; C12P21/02
摘要：
A method for producing recombinant polypeptides, including antibodies, having targeted levels of carboxyl terminal (C-terminal) lysine or arginine residues is presented. The method involves culturing cells expressing said polypeptides in cell culture medium having sufficient levels of lysine, arginine, and/or agents that change intracellular pH. Culturing the cells under such conditions does not affect cell growth, cell viability, or titer.
公开/授权文献
- US20140142286A1 CELL CULTURE PROCESS 公开/授权日：2014-05-22
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