发明授权
US09464322B2 Methods for diagnosing and treating alzheimer's disease (AD) using the molecules that stabilize intracellular calcium (Ca2+) release
有权
使用稳定细胞内钙（Ca2 +）释放的分子诊断和治疗阿尔茨海默病（AD）的方法
- 专利标题： Methods for diagnosing and treating alzheimer's disease (AD) using the molecules that stabilize intracellular calcium (Ca2+) release
- 专利标题（中）： 使用稳定细胞内钙（Ca2 +）释放的分子诊断和治疗阿尔茨海默病（AD）的方法
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申请号： US13608596申请日： 2012-09-10
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公开(公告)号： US09464322B2公开(公告)日： 2016-10-11
- 发明人: Philip W. Landfield , John Christopher Gant , Eric M. Blalock , Kuey-Chu Chen , Olivier Thibault , Nada Porter
- 申请人： Philip W. Landfield , John Christopher Gant , Eric M. Blalock , Kuey-Chu Chen , Olivier Thibault , Nada Porter
- 申请人地址： US KY Lexington
- 专利权人： UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION
- 当前专利权人： UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION
- 当前专利权人地址： US KY Lexington
- 代理机构： McDermott Will & Emery LLP
- 主分类号： A61K48/00
- IPC分类号： A61K48/00 ; C12Q1/68 ; A61K38/17 ; A61K38/52
摘要：
The subject technology relates, in part, to a method of treating Alzheimer's Disease (AD), early-stage AD, elevated risk of AD, mild cognitive impairment (MCI), or other forms of age-related cognitive decline in a subject in need thereof by administering to the subject a molecule that promotes calcium-release stabilization in ryanodine receptors (RyRs) and/or inosital triphosphate receptors (InsP3Rs) in brain cells. Diagnostic methods using calcium-release stabilizing immunophilins, junctophilins or calmodulin are also disclosed.
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