Invention Grant
US09457039B2 2′-disubstituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases
有权
2'-二取代的核苷衍生物及其用于治疗病毒性疾病的方法
- Patent Title: 2′-disubstituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases
- Patent Title (中): 2'-二取代的核苷衍生物及其用于治疗病毒性疾病的方法
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Application No.: US14436687Application Date: 2013-10-11
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Publication No.: US09457039B2Publication Date: 2016-10-04
- Inventor: Vinay Girijavallabhan , Stephane Bogen , Weidong Pan , Qun Dang , Ian Davies
- Applicant: Merck Sharp & Dohme Corp.
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent Alysia A. Finnegan; Gloria Fuentes
- International Application: PCT/CN2013/085069 WO 20131011
- International Announcement: WO2014/059902 WO 20140424
- Main IPC: C07H19/12
- IPC: C07H19/12 ; C07H19/23 ; C07D487/04 ; A61K31/706 ; A61K31/53 ; A61P31/14 ; A61K45/06 ; A61K31/7056 ; A61K38/21 ; C07H7/06
Abstract:
2′-disubstituted substituted nucleoside derivatives of formula (I) and pharmaceutically acceptable salts thereof are disclosed: (1), wherein A is N3 or NH2 and X, Y, R1, R2, R3, R4, R5 and R18 are as defined herein. Compositions comprising at least one 2′-disubstituted nucleoside derivative, and methods of using the 2′-disubstituted nucleoside derivatives for treating or preventing HCV infection in a patient are disclosed.
Public/Granted literature
- US20160045526A1 2'-DISUBSTITUTED NUCLEOSIDE DERIVATIVES AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES Public/Granted day:2016-02-18
Information query
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