A frame sealant and a sealing method, a display panel and a display device containing the frame sealant. A sealing method for a frame sealant comprises: successively coating a water-borne epoxy resin and a solvent-based epoxy resin or successively coating a solvent-based epoxy resin and a water-borne epoxy resin on a first substrate, aligning and pressing the first substrate and a second substrate; or coating a water-borne epoxy resin on a first substrate, coating a solvent-based epoxy resin on a second substrate, and aligning and pressing the two substrates; a first material by which a nano-scale second material is encapsulated is dispersed in the solvent-based epoxy resin, wherein, the first material is a hydrophilic polymeric material and the second material is one which will undergo an exothermic reaction with water. When the frame sealant is pressed, the hydrophilic polymeric material will absorb water and thus be saturated with water, the remaining water will react with the material which undergoes an exothermal reaction with water to generate heat, which will cause the curing of the frame sealant as an internal heat source.