发明授权
US09453014B2 Cyclic amide derivatives as inhibitors of 11-β-hydroxysteroid dehydrogenase and uses thereof
有权
作为11-β-羟基类固醇脱氢酶抑制剂的环状酰胺衍生物及其用途
- 专利标题： Cyclic amide derivatives as inhibitors of 11-β-hydroxysteroid dehydrogenase and uses thereof
- 专利标题（中）： 作为11-β-羟基类固醇脱氢酶抑制剂的环状酰胺衍生物及其用途
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申请号： US14367614申请日： 2012-12-21
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公开(公告)号： US09453014B2公开(公告)日： 2016-09-27
- 发明人: Jagannath Madanahalli Ranganath Rao , Uppala Venkatesham , Jenson George , George Fernand , Sivanageswara Rao Doppalapudi , G R Madhavan , Nagarajan Arumugam , Mohammed Ansari , K Murugavel , Jidugu Pradeep , Sulthan Allavuddeen , K Vijayaramalingam , Hampelingaiah Shiva Prasad , Augustine Michael Raj , S Gnanavel , Ramamoorthy Kottamalai , Naresh M P S Babu , Bommegowda Yadaganahalli Kenchegowda
- 申请人： CONNEXIOS LIFE SCIENCES PVT. LTD.
- 申请人地址： IN Bangalore
- 专利权人： Connexios Life Sciences Pvt. Ltd.
- 当前专利权人： Connexios Life Sciences Pvt. Ltd.
- 当前专利权人地址： IN Bangalore
- 代理机构： Hauptman Ham, LLP
- 优先权： IN4527/CHE/2011 20111222
- 国际申请： PCT/IN2012/000841 WO 20121221
- 国际公布： WO2013/128465 WO 20130906
- 主分类号： C07D471/04
- IPC分类号： C07D471/04 ; C07D401/06 ; C07D401/12 ; C07D403/06 ; C07D417/12 ; C07D417/06 ; C07D209/44 ; C07D405/06 ; C07D405/14 ; C07D409/14 ; C07D413/06
摘要：
The present invention relates amide compounds of formula (I): wherein R1, R1a, Ar, A, B, W1, W2, D, a, b, and c are defined herein, and pharmaceutical acceptable salts thereof. These compounds have the ability to inhibit 11-β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1) and which are therefore useful in the treatment of certain disorders that can be prevented or treated by inhibition of this enzyme. In addition the invention relates to the compounds, methods for their preparation, pharmaceutical compositions containing the compounds and the uses of these compounds in the treatment of certain disorders. It is expected that the compounds of the invention will find application in the treatment of conditions such as non-insulin dependent type 2 diabetes mellitus (NIDDM), insulin resistance, obesity, impaired fasting glucose, impaired glucose tolerance, lipid disorders such as dyslipidemia, hypertension and as well as other diseases and conditions.
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