Disclosed are various embodiments for predictive caching of content to facilitate instantaneous use of the content. If a user is likely to commence use of a content item through a client, and if the client has available resources to facilitate instantaneous use, the client is configured to predictively cache the content item before the user commences use. In doing so, the client may obtain metadata for the content item and an initial portion of the content item from a server. The client may then initialize various resources to facilitate instantaneous use of the content item by the client based at least in part on the metadata and the initial portion.