Embodiments of the present invention provide a method and a device for positioning a user equipment in a handover process. The method mainly includes: receiving, by a target base station of the user equipment in the handover process, positioning measurement related information of the user equipment transmitted from a source base station of the user equipment; and performing, by the target base station, a positioning measurement for the user equipment according to the positioning measurement related information after the user equipment has accessed the target base station successfully. Embodiments of the present invention enables the target base station to perform positioning measurement for the user equipment immediately after the UE has successfully accesses the target base station, and eliminates the need for a positioning server to retrigger a user equipment positioning process, thus reduces the signaling cost caused by retriggering the user equipment positioning process.