An array substrate, a manufacturing method thereof and a display panel are provided. The array substrate includes: a substrate; and first pixel groups and second pixel groups which are disposed on the substrate and are alternately arranged to form a pixel array. Each first pixel group includes two first pixel units, each first pixel unit includes a first pixel electrode connected with a common electrode and a second pixel electrode connected with a drain electrode of a drive TFT of the first pixel unit. Each second pixel group includes two second pixel units, each second pixel unit includes a third pixel electrode connected with a drain electrode of a drive TFT of the second pixel unit and a fourth pixel electrode connected with the common electrode.