发明授权
US09403899B2 Method for reducing the thromboembolic potential of a plasma-derived immunoglobulin composition
有权
用于降低血浆来源的免疫球蛋白组合物的血栓栓塞潜力的方法
- 专利标题： Method for reducing the thromboembolic potential of a plasma-derived immunoglobulin composition
- 专利标题（中）： 用于降低血浆来源的免疫球蛋白组合物的血栓栓塞潜力的方法
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申请号： US13595967申请日： 2012-08-27
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公开(公告)号： US09403899B2公开(公告)日： 2016-08-02
- 发明人: Wolfgang Teschner , Harald Arno Butterweck , Bernhard Kölbl , Lucia Hofbauer , Hans-Peter Schwarz
- 申请人： Wolfgang Teschner , Harald Arno Butterweck , Bernhard Kölbl , Lucia Hofbauer , Hans-Peter Schwarz
- 申请人地址： IL Bannockburn CH Glattpark (Opfikon)
- 专利权人： Baxalta Incorporated,Baxalta GmbH
- 当前专利权人： Baxalta Incorporated,Baxalta GmbH
- 当前专利权人地址： IL Bannockburn CH Glattpark (Opfikon)
- 代理机构： Morgan, Lewis & Bockius LLP
- 主分类号： C07K16/00
- IPC分类号： C07K16/00 ; C07K16/06
摘要：
The present invention provides methods for reducing the amidolytic and anti-complement activity (ACA) content of an immunoglobulin composition through the use of cation exchange chromatography. In a specific embodiment, the invention provides methods for reducing the Factor XI and/or Factor XIa and/or ACA content of an immunoglobulin composition by collecting the leading portion of a cation exchange eluate. The present invention also provides immunoglobulin composition having reduced levels of amidolytic activity, Factor XI, and/or Factor XIa, and/or ACA content.
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