发明授权
- 专利标题: Benzoxazinone amides as mineralocorticoid receptor modulators
- 专利标题(中): 苯并恶嗪酮作为盐皮质激素受体调节剂
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申请号: US14753239申请日: 2015-06-29
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公开(公告)号: US09394291B2公开(公告)日: 2016-07-19
- 发明人: Gavin O'Mahony , Michael Kossenjans , Karl Edman , Johan Kajanus , Karl Anders Hogner , Philip Cornwall , Andrew Turner
- 申请人: AstraZeneca AB
- 申请人地址: SE Sodertalje
- 专利权人: AstraZeneca AB
- 当前专利权人: AstraZeneca AB
- 当前专利权人地址: SE Sodertalje
- 主分类号: C07D413/10
- IPC分类号: C07D413/10 ; C07D413/06 ; C07D265/36
摘要:
Disclosed are certain derivatives of benzoxazinone amides of formula (I), or pharmaceutically acceptable salts thereof, that act as mineralocorticoid (MR) receptor modulators that may reduce oxidative stress in endothelium and hence improve vascular function, to methods for their potential therapeutic use, to pharmaceutical compositions containing them and to processes for preparing such compounds.
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