发明授权
- 专利标题： PKM2 modulators and methods for their use
- 专利标题（中）： PKM2调制剂及其使用方法
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申请号： US14435976申请日： 2013-10-16
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公开(公告)号： US09394257B2公开(公告)日： 2016-07-19
- 发明人: Koc-Kan Ho , Yong Xu , Michael David Saunders , Xiaohui Liu , Scott Albert Pearce , Kevin Bret Wright , Jason Marc Foulks , Kenneth Mark Parnell , Steven Brian Kanner , David Lee Vollmer , Jihua Liu
- 申请人： Tolero Pharmaceuticals, Inc.
- 申请人地址： US UT Lehi
- 专利权人： Tolero Pharmaceuticals, Inc.
- 当前专利权人： Tolero Pharmaceuticals, Inc.
- 当前专利权人地址： US UT Lehi
- 代理机构： Seed IP Law Group PLLC
- 国际申请： PCT/US2013/065296 WO 20131016
- 国际公布： WO2014/062838 WO 20140424
- 主分类号： C07D231/14
- IPC分类号： C07D231/14 ; C07D403/12 ; C07D417/12 ; C07D401/12 ; C07D417/14 ; C07D231/38 ; C07D405/12 ; C07F9/6503 ; C07D401/14 ; C07D405/14 ; C07D231/16 ; C07D403/14 ; C07D409/12 ; C07D409/14 ; C07D413/12
摘要：
Compounds having activity as PKM2 activators are disclosed. The compounds have the following structure (I): including stereoisomers, tautomers, pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R3, R4, R5 and R6 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
公开/授权文献
- US20150344436A1 PKM2 MODULATORS AND METHODS FOR THEIR USE 公开/授权日：2015-12-03
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