发明授权
- 专利标题： Silodosin intermediate and preparation method therefor
- 专利标题（中）： 西洛昔辛中间体及其制备方法
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申请号： US14365638申请日： 2012-07-27
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公开(公告)号： US09394251B2公开(公告)日： 2016-07-19
- 发明人: Bin Zhang , Xiaowei Hu , Pucha Yan , Xianyi Zhang , Hongjun Gao , Yuanqiang Li , Daqing Che
- 申请人： Bin Zhang , Xiaowei Hu , Pucha Yan , Xianyi Zhang , Hongjun Gao , Yuanqiang Li , Daqing Che
- 申请人地址： CN Taizhou, Zhejiang
- 专利权人： Zhejiang Jiuzhou Pharmaceutical Co., Ltd.
- 当前专利权人： Zhejiang Jiuzhou Pharmaceutical Co., Ltd.
- 当前专利权人地址： CN Taizhou, Zhejiang
- 优先权： CN201110440481 20111226
- 国际申请： PCT/CN2012/079253 WO 20120727
- 国际公布： WO2013/097456 WO 20130704
- 主分类号： C07D209/08
- IPC分类号： C07D209/08 ; C07F7/00 ; C07F7/02 ; C07F7/18 ; C07F9/6539
摘要：
Disclosed are a silodosin intermediate and a preparation method thereof. The silodosin intermediate has the structure shown by the formula (A). X is hydrogen or bromide and R1 is hydrogen. The formyl group may be a group having the structure shown by the formula I. R7 is a protecting group of carboxyl, and R2 is 3-hydroxypropyl or a group having the structure shown by the formula II. W is a protecting group of hydroxyl. A compound of the formula (A) according to the present invention may further be used for preparing a compound having the structure shown by the formula (D). By means of the intermediate and the preparation method therefor provided by the present invention, high-purity optically pure silodosin can be obtained, and the optical purity is above 99%.
公开/授权文献
- US20150148548A1 Silodosin Intermediate and Preparation Method Therefor 公开/授权日：2015-05-28
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