A rotational resistance system is described herein, the system being adapted for a user so as to facilitate exercise of muscles throughout upper and lower extremities of the user's body. The system may include a pair of separate rotational resistance devices in side-by-side relation for placement of a corresponding hand or foot of a user thereon. Each device may further include a support structure, a top surface of which being a rotatable plate, the plate connected to a means for providing resistance and release of resistance thereto. Use of various exercise protocols with the system activates selected under active muscles of the user and releases selected overactive muscles.