发明授权
- 专利标题： Methods for screening inhibitors of tumor associated protein aggregation
- 专利标题（中）： 筛选肿瘤相关蛋白聚集抑制剂的方法
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申请号： US14007602申请日： 2012-03-26
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公开(公告)号： US09389219B2公开(公告)日： 2016-07-12
- 发明人: Joost Schymkowitz , Frederic Rousseau , Jie Xu , Frederik De Smet
- 申请人： Joost Schymkowitz , Frederic Rousseau , Jie Xu , Frederik De Smet
- 申请人地址： BE Brussel BE Leuven
- 专利权人： Vrije Universiteit Brussel,Katholieke Universiteit Leuven, K.U. Leuven R&D
- 当前专利权人： Vrije Universiteit Brussel,Katholieke Universiteit Leuven, K.U. Leuven R&D
- 当前专利权人地址： BE Brussel BE Leuven
- 代理机构： TraskBritt, P.C.
- 国际申请： PCT/EP2012/055291 WO 20120326
- 国际公布： WO2012/130785 WO 20121004
- 主分类号： G01N31/00
- IPC分类号： G01N31/00 ; A61K38/04 ; G01N33/50 ; C12Q1/68
摘要：
The disclosure relates to the fields of protein aggregation diseases including cancer. More specifically, it concerns a screening method for identifying compounds that inhibit or disrupt co-aggregation of one or more member proteins of a disease-related protein aggregome, in particular, a tumor-associated protein aggregome. Further, disclosed are agents and compounds identified by the screening method that can be applied to prevent or to treat protein aggregation diseases, such as cancer.
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