- 专利标题: Pyrrolobenzodiazepines and targeted conjugates
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申请号: US14351168申请日: 2012-10-12
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公开(公告)号: US09387258B2公开(公告)日: 2016-07-12
- 发明人: Scott Jeffrey , Patrick Burke , Philip Wilson Howard
- 申请人: SEATTLE GENETICS, INC. , MEDIMMUNE LIMITED
- 申请人地址: US WA Bothell GB Cambridge
- 专利权人: SEATTLE GENETICS, INC.,MEDIMMUNE LIMITED
- 当前专利权人: SEATTLE GENETICS, INC.,MEDIMMUNE LIMITED
- 当前专利权人地址: US WA Bothell GB Cambridge
- 代理机构: Michael Best & Friedrich LLP
- 国际申请: PCT/US2012/059867 WO 20121012
- 国际公布: WO2013/055990 WO 20130418
- 主分类号: C07D487/04
- IPC分类号: C07D487/04 ; A61K47/48 ; C07D471/04
摘要:
A compound, or a pharmaceutically acceptable salt or solvate thereof, or conjugates thereof, selected from the group consisting of formula wherein: (a) R10 is H, and R11 is OH, ORA, where RA is saturated C1-4 alkyl; (b) R10 and R11 form a nitrogen-carbon double bond between the nitrogen and carbon atoms to which they are bound; or (c) R10 is H and R11 is S02M, where z is 2 or 3 and M is a monovalent pharmaceutically acceptable cation, or both M together are a divalent pharmaceutically acceptable cation.
公开/授权文献
- US09526798B2 Pyrrolobenzodiazepines and targeted conjugates 公开/授权日:2016-12-27
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