发明授权
- 专利标题： Oxazolidone compound, preparing method and application thereof
- 专利标题（中）： 恶唑烷酮化合物，其制备方法和应用
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申请号： US14761843申请日： 2013-12-30
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公开(公告)号： US09382265B2公开(公告)日： 2016-07-05
- 发明人: Yushe Yang , Tao Xue , Shi Ding , Bin Guo
- 申请人： SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES , ZHE JIANG JUTAI PHARMACEUTICAL CO., LTD.
- 申请人地址： CN Shanghai CN Quzhou
- 专利权人： Shanghai Institute of Materia Medica, Chinese Academy of Sciences,Zhe Jiang Jutai Pharmaceutical Co., Ltd.
- 当前专利权人： Shanghai Institute of Materia Medica, Chinese Academy of Sciences,Zhe Jiang Jutai Pharmaceutical Co., Ltd.
- 当前专利权人地址： CN Shanghai CN Quzhou
- 代理机构： Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C.
- 优先权： CN201310020040 20130118
- 国际申请： PCT/CN2013/090833 WO 20131230
- 国际公布： WO2014/110971 WO 20140724
- 主分类号： C07D498/04
- IPC分类号： C07D498/04 ; C07D519/00
摘要：
The present invention relates to the field of a pharmaceutical compound, and more specifically, relates to a new oxazolidone compound, an enantiomer, a diastereoisomer and a raceme thereof, and a mixture thereof, and a pharmaceutically acceptable salt thereof, a preparation method thereof, an application thereof as a bioactive substance in a drug. The compound in the present invention has strong anticoagulant activity, does not affect the activity of thrombin, and can reduce the risk of hemorrhage. A pharmacokinetics experiment shows that the compound in the present invention further has good metabolic characteristics, and has a far better oral bioavailability than a positive contrastive agent rivaroxaban.
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