Invention Grant
- Patent Title: Substituted pyridine spleen tyrosine kinase (SYK) inhibitors
- Patent Title (中): 取代吡啶脾酪氨酸激酶（SYK）抑制剂
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Application No.: US14409151Application Date: 2013-06-17
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Publication No.: US09376418B2Publication Date: 2016-06-28
- Inventor: Andrew M. Haidle , Sandra Lee Knowles , Solomon D. Kattar , Denis Deschenes , Jason Burch , Joel Robichaud , Matthew Christopher , Michael D. Altman , James P. Jewell , Alan B. Northrup , Marc Blouin , John Michael Ellis , Hua Zhou , Christian Fischer , Adam J. Schell , Michael H. Reutershan , Brandon M. Taoka , Anthony Donofrio
- Applicant: Merck Sharp & Dohme Corp. , Merck Canada Inc.
- Applicant Address: US NJ Rahway CA Kirkland, Quebec
- Assignee: Merck Sharp & Dohme Corp.,Merck Canada Inc.
- Current Assignee: Merck Sharp & Dohme Corp.,Merck Canada Inc.
- Current Assignee Address: US NJ Rahway CA Kirkland, Quebec
- Agent Eric A. Meade; Anna L. Cocuzzo
- International Application: PCT/US2013/046151 WO 20130617
- International Announcement: WO2013/192098 WO 20131227
- Main IPC: C07D401/12
- IPC: C07D401/12 ; C07D401/14 ; A61K31/506 ; A61K31/505 ; A61K45/06 ; A61K31/5377 ; A61K31/5383 ; A61K31/551 ; C07D405/14 ; C07D413/14 ; C07D417/14 ; C07D471/04 ; C07D471/10 ; C07D487/04 ; C07D491/107 ; C07D491/113 ; C07D498/04 ; C07D491/08 ; C07D409/14 ; C07D487/10
Abstract:
The invention provides certain substituted pyridines of the Formula (I) or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, Rcy, Cy, and t are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated by Spleen Tyrosine Kinase (Syk) kinase.
Public/Granted literature
- US20150148327A1 SUBSTITUTED PYRIDINE SPLEEN TYROSINE KINASE (SYK) INHIBITORS Public/Granted day:2015-05-28
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