A method of removing noise from a two-channel signal includes receiving channel signals constituting the two-channel signal; obtaining a noise signal for each channel by removing a target signal from each channel signal by subtracting another channel signal multiplied by a weighted value from each channel signal; estimating a power spectral density (PSD) of diffuse noise from each channel signal; obtaining a target signal including an interference signal for each channel by removing the diffuse noise from each channel signal using the estimated PSD of the diffuse noise; obtaining the interference signal for each channel by removing the diffuse noise from the noise signal for each channel using the estimated PSD of the diffuse noise; and removing the interference signal from the target signal and the interference signal for each channel.