Invention Grant
- Patent Title: Prolylcarboxypeptidase inhibitors
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Application No.: US13642646Application Date: 2011-05-06
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Publication No.: US09365539B2Publication Date: 2016-06-14
- Inventor: Jeffrey J. Hale , Jinlong Jiang , Dong-Ming Shen , Zhi-Cai Shi , Min Shu , Zhicai Wu , Cangming Yang
- Applicant: Jeffrey J. Hale , Jinlong Jiang , Dong-Ming Shen , Zhi-Cai Shi , Min Shu , Zhicai Wu , Cangming Yang
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent Baerbel R. Brown; Catherine D. Fitch
- International Application: PCT/US2011/035501 WO 20110506
- International Announcement: WO2011/143057 WO 20111117
- Main IPC: A61K31/397
- IPC: A61K31/397 ; C07D401/04 ; C07D401/14
Abstract:
Compounds of structural formula I are inhibitors of prolylcarboxypeptidase (PrCP). The compounds of the present invention are useful for the prevention and treatment of conditions related to the enzymatic activity of PrCP such as abnormal metabolism, including obesity; diabetes; metabolic syndrome; obesity related disorders; and diabetes related disorders.
Public/Granted literature
- US20130040929A1 NOVEL PROLYLCARBOXYPEPTIDASE INHIBITORS Public/Granted day:2013-02-14
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