发明授权
- 专利标题： Methods of intracellular conversion of single-chain proteins into their di-chain form
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申请号： US14038328申请日： 2013-09-26
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公开(公告)号： US09340813B2公开(公告)日： 2016-05-17
- 发明人: Sanjiv Ghanshani , Linh Q. Le , Yi Liu , Lance E. Steward
- 申请人： Allergan, Inc.
- 申请人地址： US CA Irvine
- 专利权人： Allergan, Inc.
- 当前专利权人： Allergan, Inc.
- 当前专利权人地址： US CA Irvine
- 代理商 Brigitte C. Phan; Ted C. Chan
- 主分类号： C12N9/50
- IPC分类号： C12N9/50 ; C12N9/54 ; C12P21/04 ; C12P21/00 ; C07K14/33 ; C12N15/70
摘要：
The present specification discloses expression constructs comprising single-chain proteins comprising a di-chain loop region comprising an exogenous protease cleavage site and a protease that can cleave the exogenous protease cleavage site located within the di-chain loop, cell compositions comprising such expression construct, and intracellular methods of converting the single-chain protein into its di-chain form.
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