A multi-channel transceiver includes a phase-locked loop circuit, a first transmitting channel and a second transmitting channel. The phase-locked loop circuit generates a first clock signal set and a second clock signal set with different frequencies. The first transmitting channel includes a first phase adjusting circuit and a first transmitter. The first phase adjusting circuit receives the first clock signal set and generates a first spread spectrum clock signal with a first SSCG profile. According to the first spread spectrum clock signal, the first transmitter generates a first serial data. The second transmitting channel includes a second phase adjusting circuit and a second transmitter. The second phase adjusting circuit receives the second clock signal set and generates a second spread spectrum clock signal with a second SSCG profile. According to the second spread spectrum clock signal, the second transmitter generates a second serial data.