The present invention relates to a cable sealing and retaining device capable of sealingly guiding and retaining a cable through an opening of the cable sealing and retaining device. The present invention provides an improved cable sealing and retaining device which allows a simple releasable fixation of a cable to the cable sealing and retaining device while the cable is sealingly guided through an opening provided with the cable sealing and retaining device. The cable sealing and retaining device (40;60) comprises a sealing part (11) providing a passageway with an inner seal (14) through which a cable (2) is sealingly guidable, and an outer seal (15) arranged on an outer circumference of the sealing part (11). The cable sealing and retaining device (40; 60) comprises a fixation part (12) for retaining the sealing part (11) in longitudinal direction of the passageway; and a sleeve portion (47; 67) forming an opening (41; 61) for receiving the fixation part (12) and the sealing part (11) of the cable sealing and retaining device (40; 60). The sleeve portion (47; 67) provides a sealing section (42; 62) for co-operating with the outer seal (15) to perform a sealing therebetween. The cable sealing and retaining device (40; 60) is characterized by the fixation part (12) which provides fixation means (24) on its outer circumferential surface to fix the fixation part (12) to the sleeve portion (47; 67).