A method and an apparatus for preventing an erroneous operation according to generation of an interrupt signal during separation and mounting procedures of an earphone are provided. The method includes detecting generation of an interrupt associated with a change in a connection state between the earphone and an interface unit, determining the connection state when the generation of the interrupt is detected, determining whether a preset stabilizing time for stabilizing the change in the connection state has elapsed, determining whether the determined connection state is identical with a connection state before the generation of the interrupt when the preset stabilizing time elapses, and maintaining the connection state before the generation of the interrupt when the determined connection state is identical with the connection state before the generation of the interrupt.