Invention Grant
- Patent Title: Inflammation in vivo model
- Patent Title (中): 炎症体内模型
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Application No.: US14476626Application Date: 2014-09-03
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Publication No.: US09271479B2Publication Date: 2016-03-01
- Inventor: Javier Cote-Sierra , Antonio Iglesias , Claas Aiko Meyer
- Applicant: Hoffmann-La Roche Inc.
- Applicant Address: US NJ Little Falls
- Assignee: Hoffmann-La Roche Inc.
- Current Assignee: Hoffmann-La Roche Inc.
- Current Assignee Address: US NJ Little Falls
- Agent Jennifer K. Holmes
- Priority: EP10189446 20101029
- Main IPC: A01K67/027
- IPC: A01K67/027 ; G01N33/00 ; C12N5/10 ; C12N15/85 ; A61K49/00 ; G01N33/50
Abstract:
The present invention relates to a non-human animal deficient in the N-terminal domain of the IL-33 gene. Also provided herein is the use of said non-human animal as an in vivo model of inflammatory diseases, especially with regard to screening methods for anti-inflammatory compounds, and methods for evaluating and optimizing the pharmacological properties of a given anti-inflammatory compound.
Public/Granted literature
- US20150026832A1 Novel Inflammation in Vivo Model Public/Granted day:2015-01-22
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