Invention Grant
US09255073B2 1-benzyl-3-hydroxymethylindazole derivatives and use thereof in the treatment of diseases based on the expression of MCP-1, CX3CR1 and p40
有权
1-苄基-3-羟甲基吲唑衍生物及其在治疗基于MCP-1，CX3CR1和p40表达的疾病中的应用
- Patent Title: 1-benzyl-3-hydroxymethylindazole derivatives and use thereof in the treatment of diseases based on the expression of MCP-1, CX3CR1 and p40
- Patent Title (中): 1-苄基-3-羟甲基吲唑衍生物及其在治疗基于MCP-1，CX3CR1和p40表达的疾病中的应用
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Application No.: US13898950Application Date: 2013-05-21
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Publication No.: US09255073B2Publication Date: 2016-02-09
- Inventor: Angelo Guglielmotti , Guido Furlotti , Giorgina Mangano , Nicola Cazzolla
- Applicant: AZIENDE CHIM. RIUN. ANG. FRANC. A.C.R.A.F. S.p.A.
- Applicant Address: IT Rome
- Assignee: AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.p.A.
- Current Assignee: AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.p.A.
- Current Assignee Address: IT Rome
- Agency: Oblon, McClelland, Maier & Neustadt, L.L.P.
- Priority: EP08425140 20080307
- Main IPC: A61K31/415
- IPC: A61K31/415 ; A01N43/56 ; C07D231/56 ; C07D209/00 ; C07D231/54 ; C07D401/12 ; C07D295/088
Abstract:
The present invention relates to novel 1-benzyl-3-hydroxymethylindazole derivatives according to formula (I) described in the claims, and to a pharmaceutical composition comprising them, together with a pharmaceutically acceptable vehicle. In addition, the present invention relates to the use of 1-benzyl-3-hydroxymethylindazole derivatives for the preparation of a pharmaceutical composition that is active in the treatment of diseases based on the expression of MCP-1, CX3CR1 and p40, and to their use in a method for treating or preventing diseases based on the expression of MCP-1, CX3CR1 and p40.
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